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J Virol. 2010 May;84(9):4845-50. doi: 10.1128/JVI.02514-09. Epub 2010 Feb 17.

Dengue virus inhibits the production of type I interferon in primary human dendritic cells.

Author information

1
Department of Microbiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1124, New York, NY 10029, USA.

Erratum in

  • J Virol. 2011 Mar;85(6):3042.

Abstract

Dengue virus (DENV) infects human immune cells in vitro and likely infects dendritic cells (DCs) in vivo. DENV-2 productive infection induces activation and release of high levels of chemokines and proinflammatory cytokines in monocyte-derived DCs (moDCs), with the notable exception of alpha/beta interferon (IFN-alpha/beta). Interestingly, DENV-2-infected moDCs fail to prime T cells, most likely due to the lack of IFN-alpha/beta released by moDCs, since this effect was reversed by addition of exogenous IFN-beta. Together, our data show that inhibition of IFN-alpha/beta production by DENV in primary human moDCs is a novel mechanism of immune evasion.

PMID:
20164230
PMCID:
PMC2863727
DOI:
10.1128/JVI.02514-09
[Indexed for MEDLINE]
Free PMC Article

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