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Cardiovasc Res. 2010 May 1;86(2):236-42. doi: 10.1093/cvr/cvq045. Epub 2010 Feb 17.

Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling.

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1
Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Broadway Research Building, Suite 671, 733 N. Broadway, Baltimore, MD 21205, USA.

Abstract

The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular responses, driving transcriptional activation of hundreds of genes involved in vascular reactivity, angiogenesis, arteriogenesis, and the mobilization and homing of bone marrow-derived angiogenic cells. This review will focus on the pivotal role of HIF-1 in vascular homeostasis, the involvement of HIF-1 in vascular diseases, and recent advances in targeting HIF-1 for therapy in preclinical models.

PMID:
20164116
PMCID:
PMC2856192
DOI:
10.1093/cvr/cvq045
[Indexed for MEDLINE]
Free PMC Article
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