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Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jun;109(6):831-6. doi: 10.1016/j.tripleo.2009.10.038. Epub 2010 Feb 16.

Restoration of peri-implant defects in immediate implant installations by Choukroun platelet-rich fibrin and silk fibroin powder combination graft.

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Department of Oral and Maxillofacial Surgery, Hallym University, Kyoungkido, Korea.



The objective of this study was to determine the capability of silk fibroin powder as a biomaterial template for the restoration of peri-implant defects when mixed with Choukroun platelet-rich fibrin (PRF) in vivo.


Ten New Zealand white rabbits were used for this study. Using a trephine bur (diameter 7.0 mm), 2 monocortical defects were prepared. Subsequently, 2 dental implants were installed into the tibia (diameter 3.0 mm, length 10.0 mm). In the experimental group, the peri-implant defect was filled with a combination graft of silk fibroin powder and Choukroun PRF. The control was left in an unfilled state. The animals were killed at 8 weeks. Subsequently, a removal torque test and a histomorphometric analysis were done.


The removal torque for the experimental group was 30.34 +/- 5.06, whereas it was 21.86 +/- 3.39 for the control. The difference between the 2 groups was statistically significant (P = .010). Mean new bone formation was 51.93 +/- 27.90% in the experimental group and 11.67 +/- 15.12% in the control (P = .003). Mean bone-to-implant contact was 43.07 +/- 21.96% in the experimental group and 15.37 +/- 23.84% in the control (P = .002).


A peri-implant defect can be successfully repaired by the application of Choukroun PRF and silk fibroin powder.

[Indexed for MEDLINE]

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