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Eur J Med Chem. 2010 Apr;45(4):1529-35. doi: 10.1016/j.ejmech.2010.01.001. Epub 2010 Jan 18.

Synthesis and evaluation of some new substituted benzothiazepine and benzoxazepine derivatives as anticonvulsant agents.

Author information

1
Medicinal Chemistry Division, Department of Pharmacology, L.L.R.M. Medical College, Meerut (U.P.) 250004, India.

Abstract

A new series of 4-(4'-Hydroxyphenyl)-2-(3-substitutedphenyl)-3-(4-substitutedphenylamino methylene)-2,3-dihydro-1,5-benzothiazepines (3a-3j) and 4-(4'-Hydroxyphenyl)-2-(3-substituted phenyl)-3-(4-substitutedphenylaminomethylene)-2,3-dihydro-1,5-benzoxazepins (3a'-3j') were synthesized and evaluated for their anticonvulsant activity. All these compounds were screened in vivo, for their anticonvulsant activity and acute toxicity. Compound 3g was found to be most potent compound of this series and was compared with the reference drug phenytion sodium. The structures of these compounds have been established by IR, (1)H NMR and (13)C NMR spectroscopic data.

PMID:
20163892
DOI:
10.1016/j.ejmech.2010.01.001
[Indexed for MEDLINE]

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