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Nano Lett. 2010 Mar 10;10(3):1093-7. doi: 10.1021/nl1002526.

Hydrazone ligation strategy to assemble multifunctional viral nanoparticles for cell imaging and tumor targeting.

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1
Department of Cell Biology.

Abstract

Multivalent nanoparticle platforms are attractive for biomedical applications because of their improved target specificity, sensitivity, and solubility. However, their controlled assembly remains a considerable challenge. An efficient hydrazone ligation chemistry was applied to the assembly of Cowpea mosaic virus (CPMV) nanoparticles with individually tunable levels of a VEGFR-1 ligand and a fluorescent PEGylated peptide. The nanoparticles recognized VEGFR-1 on endothelial cell lines and VEGFR1-expressing tumor xenografts in mice, validating targeted CPMV as a nanoparticle platform in vivo.

PMID:
20163184
PMCID:
PMC3988696
DOI:
10.1021/nl1002526
[Indexed for MEDLINE]
Free PMC Article
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