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Acta Gastroenterol Belg. 2009 Oct-Dec;72(4):407-12.

Expression of claudin-4 and beta-catenin in gastric premalignant lesions.

Author information

1
Inonu University Medical Faculty, Department of Gastroenterology, Malatya, Turkey. yuksel_seckin@hotmail.com

Abstract

BACKGROUND AND STUDY AIMS:

Abnormal expression of claudin-4 and beta-catenin play a role in carcinogenesis. The purpose of the present study was to examine claudin-4 and beta-catenin expression in normal and precancerous gastric mucosa.

PATIENTS AND METHODS:

Endoscopic biopsy specimens [normal gastric mucosa (n = 22), intestinal metaplasia (n = 24), dysplasia (n = 18), Helicobacter pylori (H. pylori)-associated chronic gastritis (n = 32) and remnant gastric mucosa (n = 18)] obtained from different 114 patients were examined by immunohistochemistry.

RESULTS:

Claudin-4 expression was present in 94.4% of dysplasia, 87.5% of intestinal metaplasia, 62.5% H. pylori-associated chronic gastritis, and 88.9% remnant gastric mucosa but only 18.2% of normal gastric mucosa biopsies. Decreased expression of beta-catenin was present in 27.8% of dysplasia, 8.3% of intestinal metaplasia, 15.6% of H. pylori-associated chronic gastritis, and 22.2% of remnant gastric mucosa biopsies, but was not present in normal gastric mucosa. When compared with normal gastric mucosa, there was a significant difference in claudin-4 expression in all groups (P < 0.05), but a significant difference was detected in dysplasia and remnant gastric mucosa for beta-catenin (P < 0.05).

CONCLUSIONS:

Our results suggest that claudin-4 expression is upregulated in premalignant gastric alterations.

PMID:
20163034
[Indexed for MEDLINE]

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