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Int J Mol Sci. 2009 Dec 24;11(1):1-13. doi: 10.3390/ijms11010001.

Chalcones enhance TRAIL-induced apoptosis in prostate cancer cells.

Author information

1
Department of Microbiology and Immunology, Medical University of Silesia in Katowice, Jordana, Zabrze, Poland. eszliszka@sum.edu.pl

Abstract

Chalcones exhibit chemopreventive and antitumor effects. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a naturally occurring anticancer agent that induces apoptosis in cancer cells and is not toxic to normal cells. We examined the cytotoxic and apoptotic effect of five chalcones in combination with TRAIL on prostate cancer cells. The cytotoxicity was evaluated by the MTT and LDH assays. The apoptosis was determined using flow cytometry with annexin V-FITC. Our study showed that all five tested chalcones: chalcone, licochalcone-A, isobavachalcone, xanthohumol, butein markedly augmented TRAIL-mediated apoptosis and cytotoxicity in prostate cancer cells and confirmed the significant role of chalcones in chemoprevention of prostate cancer.

KEYWORDS:

TRAIL (tumor necrosis factor-related apoptosis-inducing ligand); apoptosis; chalcones; chemoprevention; prostate cancer

PMID:
20161998
PMCID:
PMC2820986
DOI:
10.3390/ijms11010001
[Indexed for MEDLINE]
Free PMC Article

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