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Afr J Tradit Complement Altern Med. 2007 Feb 16;4(3):345-51.

Apoptosis inducing effect of andrographolide on TD-47 human breast cancer cell line.

Author information

1
Department of Natural Product Sciences, Faculty of Pharmacy Airlangga University, Surabaya, Indonesia.

Abstract

Andrographolide isolated from Andrographis paniculata Ness (Acanthaceae) at 0.35 mM, 0.70 mM and 1.40 mM induced DNA fragmentation and increased the percentage of apoptotic cells when TD-47 human breast cancer cell line was treated for 24, 48 and 72 h. The results demonstrated that andrographolide can induce apoptosis in TD-47 human breast cancer cell line in a time and concentration-dependent manner by increase expression of p53, bax, caspase-3 and decrease expression of bcl-2 determined by immunohistochemical analysis.

KEYWORDS:

Andrographis paniculata Ness; TD-47 cell; andrographolide; apoptosis

PMID:
20161898
PMCID:
PMC2816486

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