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Expert Rev Clin Immunol. 2010 Jan;6(1):101-9. doi: 10.1586/eci.09.74.

The link between allergies and eosinophilic esophagitis: implications for management strategies.

Author information

1
Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, 3550 Market Street, Philadelphia, PA 19104, USA. brownte@email.chop.edu

Abstract

Eosinophilic esophagitis (EE) has an increased incidence of diagnosis similar to other atopic diseases. We present a recent literature review of the common features between atopic diseases (i.e., asthma, allergic rhinitis and atopic dermatitis) and EE. All of the disorders have allergen triggers and evidence of a possible Th2 inflammation at the site of disease. Murine models have also shown similar features with the importance of T cells and Th2 cytokines for the development of disease. The diseases share underlying inflammation with the potential for remodeling with an increase in TGF-beta expression in asthma and EE. However, differences do exist between the diseases in treatment and pathogenesis. For EE, there are two basic treatment options: avoidance of the food triggers or treatment of the eosinophilic inflammation with corticosteroids.

KEYWORDS:

Th2 cytokines; allergic rhinitis; asthma; eosinophilic esophagitis; murine models

PMID:
20161677
PMCID:
PMC2821054
DOI:
10.1586/eci.09.74
[Indexed for MEDLINE]
Free PMC Article

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