Format

Send to

Choose Destination
Opt Lett. 2010 Feb 15;35(4):532-4. doi: 10.1364/OL.35.000532.

Multiphoton coherence domain molecular imaging with pump-probe optical coherence microscopy.

Author information

1
Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843, USA.

Abstract

We have developed a high-resolution molecular imaging technique, pump-probe optical coherence microscopy (PPOCM), based on the fusion of pump-probe spectroscopy and optical coherence microscopy. We have demonstrated the prototype system on a fixed human skin sample containing a nodular melanoma. The results indicate that the PPOCM can clearly provide a strong contrast between the melanotic and amelanotic regions. Potential applications of the PPOCM imaging of melanin include the early diagnosis of melanoma and the mapping of tumor margins during excision. The technique may in general be applied to any biological chromophore with a known absorption spectrum.

PMID:
20160808
PMCID:
PMC2839887
DOI:
10.1364/OL.35.000532
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Optical Society of America Icon for PubMed Central
Loading ...
Support Center