Send to

Choose Destination
See comment in PubMed Commons below
Epigenetics. 2010 Feb 16;5(2):105-11. Epub 2010 Feb 13.

Tuning acetylated chromatin with HAT inhibitors: a novel tool for therapy.

Author information

Istituto di Biologia e Patologia Molecolari, CNR, Sapienza Università di Roma, Roma, Italy.


Epigenetics, the heritable changes that do not involve DNA sequences, give dynamic propulsion to a static genome and modulate genome accessibility by acting through multiple layers of regulation, ultimately ending with a variable organization of chromatin. The main player in chromatin reprograming is the nucleosome, which modifies its association to DNA depending on a variety of post-translational modifications (PTMs) on histone tails. PTMs act directly on higher order chromatin structures and affect the degree of DNA wrap around the histone octamer and the interaction and/or sequential recruitment of chromatin-associated proteins and transcription factors at defined regions. Recently genomic approaches revealed a far more complex epigenome involving key proteins of cell signaling.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center