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Cell Host Microbe. 2010 Feb 18;7(2):90-9. doi: 10.1016/j.chom.2010.01.008.

Eating at the table of another: metabolomics of host-parasite interactions.

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1
Lewis-Sigler Institute for Integrative Genomics, Princeton University, NJ 08544, USA.

Abstract

The application of metabolomics, the global analysis of metabolite levels, to the study of protozoan parasites has become an important tool for understanding the host-parasite relationship and holds promise for the development of direly needed therapeutics and improved diagnostics. Research advances over the past decade have opened the door for a systems biology approach to protozoan parasites with metabolomics, providing a crucial readout of metabolic activity. In this review, we highlight recent metabolomic approaches to protozoan parasites, including metabolite profiling, integration with genomics, transcription, and proteomic analysis, and the use of metabolic fingerprints for the diagnosis of parasitic infections.

PMID:
20159614
PMCID:
PMC2825149
DOI:
10.1016/j.chom.2010.01.008
[Indexed for MEDLINE]
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