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Dev Cell. 2010 Feb 16;18(2):170-2. doi: 10.1016/j.devcel.2010.01.013.

A PAK-activated linker for EGFR and FAK.

Author information

1
Department of Reproductive Medicine, University of California, San Diego, Moores Cancer Center, La Jolla, CA 92093, USA.

Abstract

Transmembrane growth factor and integrin matrix receptors form multiprotein signaling complexes with FAK, a cytoplasmic cell motility-associated kinase. In a recent issue of Molecular Cell, Long et al. now show that a PAK-phosphorylated alternate-spliced isoform of the steroid receptor coactivator-3 (SRC-3Delta4) bridges EGFR and FAK, enhancing breast carcinoma cell migration and metastasis.

PMID:
20159588
PMCID:
PMC3081666
DOI:
10.1016/j.devcel.2010.01.013
[Indexed for MEDLINE]
Free PMC Article

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