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Mol Cell. 2010 Feb 12;37(3):299-310. doi: 10.1016/j.molcel.2010.01.025.

The BCL-2 family reunion.

Author information

1
Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

Abstract

B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways. Here we will discuss the mechanisms and functions of the BCL-2 family in the context of these pathways, highlighting the complex integration and regulation of the BCL-2 family in cell fate decisions.

PMID:
20159550
PMCID:
PMC3222298
DOI:
10.1016/j.molcel.2010.01.025
[Indexed for MEDLINE]
Free PMC Article

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