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Mol Cell. 2010 Feb 12;37(3):297-8. doi: 10.1016/j.molcel.2010.01.027.

The fast track to multidrug resistance.

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1
Infectious Disease Initiative, The Broad Institute, Cambridge, MA 02141, USA; Massachusetts General Hospital, Boston, MA 02114, USA.

Abstract

In this issue of Molecular Cell, Kohanski et al. (2010) demonstrate that even subinhibitory concentrations of bactericidal antibiotics result in the generation of reactive oxygen species, leading to an increase in mutation rate and the emergence of multidrug-resistant bacterial strains.

PMID:
20159549
DOI:
10.1016/j.molcel.2010.01.027
[Indexed for MEDLINE]
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