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Lancet. 2010 Feb 13;375(9714):594-605. doi: 10.1016/S0140-6736(09)61495-1.

Liver disease in pregnancy.

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Institute of Liver Studies, King's College Hospital, London, UK.


Severe liver disease in pregnancy is rare. Pregnancy-related liver disease is the most frequent cause of liver dysfunction in pregnancy and provides a real threat to fetal and maternal survival. A rapid diagnosis differentiating between liver disease related and unrelated to pregnancy is required in women who present with liver dysfunction during pregnancy. Research has improved our understanding of the pathogenesis of pregnancy-related liver disease, which has translated into improved maternal and fetal outcomes. Here, we provide an overview of liver diseases that occur in pregnancy, an update on the key mechanisms involved in their pathogenesis, and assessment of available treatment options.

[Indexed for MEDLINE]

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