Send to

Choose Destination
Contraception. 2010 Mar;81(3):232-9. doi: 10.1016/j.contraception.2009.10.011. Epub 2009 Nov 22.

Results of a safety and feasibility study of the diaphragm used with ACIDFORM Gel or K-Y Jelly.

Author information

Reproductive Health and HIV Research Unit, University of the Witwatersrand, Hugh Solomon Building, Hillbrow Health Precinct, Johannesburg, South Africa.



New strategies are needed for preventing HIV infection in women. One potential approach is female-initiated use of an effective topical microbicidal gel in combination with a cervical barrier such as the diaphragm.


Randomized, placebo-controlled safety and feasibility trial of diaphragm with vaginal gel during 6 months of use among 120 HIV-negative sexually active women in Johannesburg, South Africa.


Pelvic event rates were 338.3 and 247.1 per 100 women-years in the ACIDFORM gel (plus diaphragm) and K-Y(R) Jelly (plus diaphragm) groups, respectively, with a rate ratio of 1.37 (95% CI: 0.89-2.11). Most women found diaphragm with gel use acceptable.


There was a trend towards more safety events in the ACIDFORM plus diaphragm group, although no primary comparisons achieved statistical significance. Adding an effective microbicidal gel to a mechanical barrier may still prove to be an important and acceptable combination method to help prevent pregnancy and HIV/sexually transmitted infection transmission.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center