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Immune Netw. 2009 Oct;9(5):147-52. doi: 10.4110/in.2009.9.5.147. Epub 2009 Oct 30.

The prospects of vitamin C in cancer therapy.

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Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University College of Medicine, Seoul 110-744, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea.


Ascorbate (vitamin C) is a cofactor for a number of metabolic enzymes and is an indisputable essential vitamin C for humans. However, the potential of ascorbate as an anticancer agent has been a topic of controversy. A number of previous reports have addressed both positive aspects and limitations of ascorbate in cancer therapy. In this review, we briefly summarize the potential antitumor effects of ascorbate and its prospects for clinical use.


antioxidant; ascorbate; ascorbic acid; cancer; chemotherapy; cytotoxicity; intravenous; prooxidant; tumor growth; vitamin C

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