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Aging (Albany NY). 2009 Jul 24;1(8):714-22.

Human insulin/IGF-1 and familial longevity at middle age.

Author information

1
Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC, Leiden, the Netherlands.

Abstract

Recently, we have shown that compared to controls, long-lived familial nonagenarians (mean age: 93.4 years) from the Leiden Longevity Study displayed a lower mortality rate, and their middle-aged offspring displayed a lower prevalence of cardio-metabolic diseases, including diabetes mellitus. The evolutionarily conserved insulin/IGF-1 signaling (IIS) pathway has been implicated in longevity in model organisms, but its relevance for human longevity has generated much controversy. Here, we show that compared to their partners, the offspring of familial nonagenarians displayed similar non-fasted serum levels of IGF-1, IGFBP3 and insulin but lower non-fasted serum levels of glucose, indicating that familial longevity is associated with differences in insulin sensitivity.

KEYWORDS:

IGF-1; IGFBP3; familial longevity; glucose handling; height

PMID:
20157552
PMCID:
PMC2806046
DOI:
10.18632/aging.100071
[Indexed for MEDLINE]
Free PMC Article

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