Send to

Choose Destination
Nat Rev Microbiol. 2010 Mar;8(3):171-84. doi: 10.1038/nrmicro2297.

Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens.

Author information

Centre of Microbial and Plant Genetics, K.U.Leuven, Kasteelpark Arenberg 20, bus 2460, B-3001 Leuven, Belgium.


How can probiotic bacteria transduce their health benefits to the host? Bacterial cell surface macromolecules are key factors in this beneficial microorganism-host crosstalk, as they can interact with host pattern recognition receptors (PRRs) of the gastrointestinal mucosa. In this Review, we highlight the documented signalling interactions of the surface molecules of probiotic bacteria (such as long surface appendages, polysaccharides and lipoteichoic acids) with PRRs. Research on host-probiotic interactions can benefit from well-documented host-microorganism studies that span the spectrum from pathogenicity to mutualism. Distinctions and parallels are therefore drawn with the interactions of similar molecules that are presented by gastrointestinal commensals and pathogens.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center