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Nat Rev Immunol. 2010 Mar;10(3):170-81. doi: 10.1038/nri2711. Epub 2010 Feb 15.

The regulation of IL-10 production by immune cells.

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Life and Health Sciences Research Institute, University of Minho, Braga, Portugal.


Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central role in infection by limiting the immune response to pathogens and thereby preventing damage to the host. Recently, an increasing interest in how IL10 expression is regulated in different immune cells has revealed some of the molecular mechanisms involved at the levels of signal transduction, epigenetics, transcription factor binding and gene activation. Understanding the specific molecular events that regulate the production of IL-10 will help to answer the remaining questions that are important for the design of new strategies of immune intervention.

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