Format

Send to

Choose Destination
Nat Rev Immunol. 2010 Mar;10(3):193-200. doi: 10.1038/nri2727. Epub 2010 Feb 15.

Organization of immunological memory by bone marrow stroma.

Author information

1
German Rheumatism Research Center, A Leibniz Institute, Berlin, Germany.

Abstract

Immunological memory is a hallmark of the adaptive immune system. Plasma cells and memory B and T cells collectively provide protective immunity and effective secondary immune responses to invading pathogens. Here, we discuss how mesenchymal stromal cells regulate immunological memory by organizing defined numbers of dedicated survival niches for plasma cells and memory T cells in the bone marrow and also, to a lesser extent, in secondary lymphoid organs. An understanding of the biology of mesenchymal stromal cells and their interaction with cells of the immune system is key to fully understanding immunological memory.

PMID:
20154734
DOI:
10.1038/nri2727
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center