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Schizophr Bull. 2010 Mar;36(2):243-5. doi: 10.1093/schbul/sbq004. Epub 2010 Feb 12.

Mutant mouse models: phenotypic relationships to domains of psychopathology and pathobiology in schizophrenia.

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1
Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen's Green, Dublin 2, Ireland. cotuathaigh@rcsi.ie

Abstract

The present series of review articles seeks to elaborate how current findings in mutant mice may inform on the relationship between candidate genes and individual psychopathological and pathobiological aspects of schizophrenia. Each of the authors focuses on an overlapping selection of both well-characterized and emergent candidate genes, as identified through association and linkage studies and/or via their involvement in putative pathophysiological mechanisms, particularly those relating to dopaminergic and glutamatergic processes.

PMID:
20154202
PMCID:
PMC2833133
DOI:
10.1093/schbul/sbq004
[Indexed for MEDLINE]
Free PMC Article
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