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Vaccine. 2010 May 21;28(23):3997-4001. doi: 10.1016/j.vaccine.2010.01.064. Epub 2010 Feb 12.

The secretome of a recombinant BCG substrain reveals differences in hypothetical proteins.

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1
Programa de Inmunología Molecular Microbiana, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Edificio de Investigación, 4 degrees piso, Av. Universidad #3000, Coyoacán, 04510 México, D.F., Mexico.

Abstract

Tuberculosis remains a major human health problem worldwide, and strategies for its prevention include the generation and characterization of new recombinant vaccines containing immunodominant antigens from Mycobacterium tuberculosis. By comparing the secretomes of wild-type Mycobacterium bovis and a PstS1-recombinant M. bovis BCG vaccine substrain (rBCG38), we identified six conserved hypothetical proteins (BCG2696, BCG1674, BCG0372, BCG0427, BCG2436c, and BCG3053) that are differentially expressed. Our findings will aid in the identification of highly immunogenic proteins present in rBCG.

PMID:
20153797
DOI:
10.1016/j.vaccine.2010.01.064
[Indexed for MEDLINE]
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