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Bioorg Med Chem Lett. 2010 Mar 15;20(6):2038-43. doi: 10.1016/j.bmcl.2009.09.071. Epub 2009 Sep 22.

Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)--against colon cancer.

Author information

1
Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. ddesai@psu.edu

Abstract

Our studies demonstrate that substitution of sulfur with selenium in known iNOS inhibitor increases the compound's potency by several folds in variety of different cancers cell lines tested. Hence, this approach may be used as a strategy to increase the efficacy of the anticancer agents.

PMID:
20153642
PMCID:
PMC2892985
DOI:
10.1016/j.bmcl.2009.09.071
[Indexed for MEDLINE]
Free PMC Article

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