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FEBS Lett. 2010 Apr 2;584(7):1374-8. doi: 10.1016/j.febslet.2010.02.017. Epub 2010 Feb 12.

Physiological significance of selective degradation of p62 by autophagy.

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1
Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan. komatsu-ms@igakuken.or.jp

Abstract

Autophagy is a highly conserved bulk protein degradation pathway responsible for the turnover of long-lived proteins, disposal of damaged organelles, and clearance of aggregate-prone proteins. Thus, inactivation of autophagy results in cytoplasmic protein inclusions, which are composed of misfolded proteins and excess accumulation of deformed organelles, leading to liver injury, diabetes, myopathy, and neurodegeneration. Although autophagy has been considered non-selective, growing lines of evidence indicate the selectivity of autophagy in sorting vacuolar enzymes and in the removal of aggregate-prone proteins, unwanted organelles and microbes. Such selectivity by autophagy enables diverse cellular regulations, similar to the ubiquitin-proteasome pathway. In this review, we introduce the selective turnover of the ubiquitin- and LC3-binding protein 'p62' through autophagy and discuss its physiological significance.

PMID:
20153326
DOI:
10.1016/j.febslet.2010.02.017
[Indexed for MEDLINE]
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