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Trends Immunol. 2010 Mar;31(3):103-9. doi: 10.1016/j.it.2009.12.009. Epub 2010 Feb 10.

The immunobiology of aluminium adjuvants: how do they really work?

Author information

1
The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, ST5 5BG, UK. c.exley@chem.keele.ac.uk

Abstract

Aluminium adjuvants potentiate the immune response, thereby ensuring the potency and efficacy of typically sparingly available antigen. Their concomitant critical importance in mass vaccination programmes may have prompted recent intense interest in understanding how they work and their safety. Progress in these areas is stymied, however, by a lack of accessible knowledge pertaining to the bioinorganic chemistry of aluminium adjuvants, and, consequently, the inappropriate application and interpretation of experimental models of their mode of action. The objective herein is, therefore, to identify the many ways that aluminium chemistry contributes to the wide and versatile armoury of its adjuvants, such that future research might be guided towards a fuller understanding of their role in human vaccinations.

PMID:
20153253
DOI:
10.1016/j.it.2009.12.009
[Indexed for MEDLINE]

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