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Psychiatry Res. 2010 Mar 30;181(3):233-6. doi: 10.1016/j.pscychresns.2009.12.001. Epub 2010 Feb 12.

Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder.

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  • 1Department of Psychology, Drexel University, Philadelphia, PA, United States.


Frontal systems dysfunction and abandonment fears represent central features of borderline personality disorder (BPD). BPD subjects (n=10) and matched non-psychiatric comparison subjects (n=10) completed a social-cognitive task with two confederates instructed to either include or exclude subjects from a circumscribed interaction. Evoked cerebral blood oxygenation in frontal cortex was measured using 16-channel functional near infrared spectroscopy. BPD subjects showed left medial prefrontal cortex hyperactivation during social exclusion suggesting potential dysfunction of frontolimbic circuitry.

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