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J Neuroimmunol. 2010 Mar 30;220(1-2):136-9. doi: 10.1016/j.jneuroim.2010.01.013. Epub 2010 Feb 11.

Progesterone treatment reduces disease severity and increases IL-10 in experimental autoimmune encephalomyelitis.

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1
Neuroimmunology Research, Portland VA Medical Center, Portland, OR, United States.

Abstract

Ovarian hormones, including progesterone, are known to have immunomodulatory and neuroprotective effects which may alter the disease course of experimental autoimmune encephalomyelitis (EAE). In the current study, we examined the treatment potential of progesterone beginning at the onset of EAE symptoms. Progesterone treated animals showed reduced peak disease scores and cumulative disease indices, and decreased inflammatory cytokine secretion (IL-2 and IL-17). In addition, increased production of IL-10 was accompanied by increased numbers of CD19+ cells and an increase in CD8+ cells. Decreased chemokine and chemokine receptor expression in the spinal cord also contributed to decreased lesions in the spinal cord.

PMID:
20153059
PMCID:
PMC2835841
DOI:
10.1016/j.jneuroim.2010.01.013
[Indexed for MEDLINE]
Free PMC Article

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