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J Clin Endocrinol Metab. 2010 Apr;95(4):1786-92. doi: 10.1210/jc.2009-2106. Epub 2010 Feb 11.

Serum anti-mullerian hormone concentrations are elevated in oligomenorrheic girls without evidence of hyperandrogenism.

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  • 1Department of Reproductive Medicine, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, California 92093-0633, USA.

Abstract

CONTEXT:

Serum anti-Müllerian hormone (AMH) levels are significantly elevated in adolescents with polycystic ovary syndrome (PCOS) compared to normal controls. Whether adolescents with oligomenorrhea have elevated AMH levels is unknown.

OBJECTIVE:

This study was performed to assess serum AMH levels in oligomenorrheic (OLIGO) girls without evidence of hyperandrogenism.

DESIGN:

This was a prospective study comparing AMH levels in OLIGO, PCOS, and normal control adolescents.

SETTING:

The study was conducted through four tertiary academic medical centers.

PARTICIPANTS:

The study groups were comprised of OLIGO (n = 24), PCOS (n = 153), and normal adolescent girls (n = 39), as well as PCOS (n = 73) and normal adult women (n = 36).

INTERVENTIONS:

In each subject, serum AMH levels were assessed in the early to midfollicular phases for regularly menstruating subjects and on an arbitrary day for OLIGO or PCOS subjects.

MAIN OUTCOME MEASURE(S):

Basal serum AMH levels were assessed among OLIGO, PCOS, and normal girls, in addition to PCOS and normal women.

RESULTS:

OLIGO girls had serum AMH levels (5.33 +/- 0.47 ng/ml) that were significantly greater than the normal adolescents (3.05 +/- 0.31 ng/ml) and adults (2.33 +/- 0.22 ng/ml), but similar to values seen in the PCOS adolescents (5.28 +/- 0.26 ng/ml) and adults (6.36 +/- 0.47 ng/ml). Obese adolescents and PCOS women had significantly lower AMH levels compared to lean controls (P < 0.02).

CONCLUSION:

In OLIGO adolescents, elevated serum AMH levels suggest increased antral follicle number similar to that observed in girls with PCOS.

PMID:
20150576
PMCID:
PMC2853993
DOI:
10.1210/jc.2009-2106
[PubMed - indexed for MEDLINE]
Free PMC Article
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