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J Am Soc Nephrol. 2010 Mar;21(3):406-12. doi: 10.1681/ASN.2009080820. Epub 2010 Feb 11.

Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK.

Author information

1
Division of Nephrology and Hypertension, Department of Medicine, University of California-San Diego/Veterans Affairs San Diego Healthcare System, CA 92093-0711, USA.

Abstract

Obesity is a risk factor for chronic kidney disease (CKD) and nonalcoholic fatty liver disease (NAFLD). Recent studies identify mechanisms common to both diseases linked through an interorgan communication orchestrated by fetuin-A and adiponectin. In liver and kidney, the energy sensor 5'-AMP activated protein kinase (AMPK) is pivotal to directing podocytes and hepatocytes to compensatory and potentially deleterious pathways, leading to inflammatory and profibrotic cascades culminating in end-organ damage. Regulation of these early upstream pathways may provide new therapeutic targets for these increasingly common sequelae of obesity.

PMID:
20150538
PMCID:
PMC4473254
DOI:
10.1681/ASN.2009080820
[Indexed for MEDLINE]
Free PMC Article

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