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Science. 2010 Feb 12;327(5967):866-8. doi: 10.1126/science.1181185.

Vibrio cholerae VpsT regulates matrix production and motility by directly sensing cyclic di-GMP.

Author information

1
Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.

Abstract

Microorganisms can switch from a planktonic, free-swimming life-style to a sessile, colonial state, called a biofilm, which confers resistance to environmental stress. Conversion between the motile and biofilm life-styles has been attributed to increased levels of the prokaryotic second messenger cyclic di-guanosine monophosphate (c-di-GMP), yet the signaling mechanisms mediating such a global switch are poorly understood. Here we show that the transcriptional regulator VpsT from Vibrio cholerae directly senses c-di-GMP to inversely control extracellular matrix production and motility, which identifies VpsT as a master regulator for biofilm formation. Rather than being regulated by phosphorylation, VpsT undergoes a change in oligomerization on c-di-GMP binding.

PMID:
20150502
PMCID:
PMC2828054
DOI:
10.1126/science.1181185
[Indexed for MEDLINE]
Free PMC Article

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