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Trends Endocrinol Metab. 2010 Jun;21(6):375-84. doi: 10.1016/j.tem.2010.01.003. Epub 2010 Feb 10.

Vitamin D: newly discovered actions require reconsideration of physiologic requirements.

Author information

1
Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA. daniel.bikle@ucsf.edu

Abstract

Vitamin D is not just for preventing rickets and osteomalacia. Recent findings in animal experiments, epidemiologic studies and clinical trials indicate that adequate vitamin D levels are important for cancer prevention, controlling hormone levels and regulating the immune response. Although 25 hydroxyvitamin D (25OHD) levels >10 ng/ml can prevent rickets and osteomalacia, these levels are not sufficient to provide these more recently discovered clinical benefits. Rather, levels of 25OHD >30 ng/ml are generally recommended. Determining optimal levels of 25OHD and the amount of vitamin D supplementation required to achieve those levels for the numerous actions of vitamin D will only be established with additional trials. In this review, these newer applications are summarized and therapeutic considerations are provided.

PMID:
20149679
PMCID:
PMC2880203
DOI:
10.1016/j.tem.2010.01.003
[Indexed for MEDLINE]
Free PMC Article
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