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Curr Opin Struct Biol. 2010 Apr;20(2):210-6. doi: 10.1016/j.sbi.2010.01.004. Epub 2010 Feb 9.

Virus particle maturation: insights into elegantly programmed nanomachines.

Author information

1
Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. jackj@scripps.edu

Abstract

Similar modes of virus maturation have been observed in dsDNA bacteriophages and the structurally related herpes viruses and some type of maturation occur in most animal viruses. Recently a variety of biophysical studies of maturation intermediates of bacteriophages P22, lambda, and HK97 have suggested an energy landscape that drives the transitions and structure-based mechanisms for its formation. Near-atomic resolution models of subunit tertiary structures in an early intermediate of bacteriophage HK97 maturation revealed a remarkable distortion of the secondary structures when compared to the mature particle. Scaffolding proteins may induce the distortion that is maintained by quaternary structure interactions following scaffold release, making the intermediate particle metastable.

PMID:
20149636
PMCID:
PMC2854226
DOI:
10.1016/j.sbi.2010.01.004
[Indexed for MEDLINE]
Free PMC Article

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