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Fertil Steril. 2010 Nov;94(6):2128-34. doi: 10.1016/j.fertnstert.2009.12.051. Epub 2010 Feb 10.

Serum inhibin-b in fertile men is strongly correlated with low but not high sperm counts: a coordinated study of 1,797 European and US men.

Author information

1
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark. Niels.Joergensen@rh.regionh.dk

Abstract

OBJECTIVE:

To describe associations between serum inhibin-b and sperm counts, adjusted for effect of time of blood sampling, in larger cohorts than have been previously reported.

DESIGN:

Cross-sectional studies of spermatogenesis markers.

SETTING:

Four European and four US centers.

PATIENT(S):

Fertile men (1,797) were included and examined from October 1996-February 2005.

INTERVENTION(S):

The study was observational and therefore without any intervention.

MAIN OUTCOME MEASURE(S):

Associations between inhibin-b and semen variables controlled for time of blood sampling and other covariates.

RESULT(S):

Inhibin-b decreased about 2.00% per hour from 8 am-12 pm and then about 3.25% per hour from 12 pm-4 pm. There was a strong positive association between inhibin-b levels less than 150 pg/mL and both sperm concentration and total sperm count (slopes of the regression lines were β=0.011 and β=0.013 for natural logarithm-transformed sperm concentration and total sperm count, respectively). For inhibin-b levels of 150-300 pg/mL the associations were not as steep (β=0.002), but still significant. For inhibin-b levels more than 300 pg/mL there was little association to the sperm counts. Neither sperm motility nor morphology was significantly related to inhibin-b level in any group.

CONCLUSION(S):

Serum inhibin-b levels decrease nonlinearly during the daytime, and are positively correlated with sperm counts, but the predictive power is best when inhibin-b is low.

PMID:
20149358
PMCID:
PMC5034728
DOI:
10.1016/j.fertnstert.2009.12.051
[Indexed for MEDLINE]
Free PMC Article

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