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Dev Growth Differ. 2010 May;52(4):335-42. doi: 10.1111/j.1440-169X.2009.01163.x. Epub 2010 Apr 5.

Alternative splicing of SMADs in differentiation and tissue homeostasis.

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Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore.


Tissue-specific alternate splicing is an important means of regulating gene expression during development. The effector proteins for the transforming growth factor-beta signaling pathway, the SMADs, encode distinct isoforms generated via alternate splicing, which appear to have distinct tissue-specific expression profiles and functions. Here, we discuss the roles of various SMAD isoforms, and the consequences of mis-regulation of SMAD splicing in development and tissue homeostasis.

[Indexed for MEDLINE]

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