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Bipolar Disord. 2010 Feb;12(1):102-6. doi: 10.1111/j.1399-5618.2009.00771.x.

Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [Tc] TRODAT-1.

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1
Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan.

Abstract

OBJECTIVES:

Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients.

METHODS:

Seventeen drug-free euthymic bipolar patients were recruited. The availability of DAT was approximated using single photon emission computed tomography (SPECT) with [99mTc] TRODAT-1.

RESULTS:

Compared to the controls, the euthymic bipolar patients had significantly higher availability of striatal DAT.

CONCLUSIONS:

Even for patients in the euthymic state, the DAT availability is still higher than that of the controls.

[Indexed for MEDLINE]

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