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Nature. 2010 Feb 11;463(7282):E6-7. doi: 10.1038/nature08751.

Chronic DLL4 blockade induces vascular neoplasms.

Author information

1
Department of Tumor Biology and Angiogenesis, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA. minhong@gene.com

Abstract

Delta-like 4 (DLL4)-mediated Notch signalling has emerged as an attractive target for cancer therapy. However, the potential side effects of blocking this pathway remain uncertain. Here we show that chronic DLL4 blockade causes pathological activation of endothelial cells, disrupts normal organ homeostasis and induces vascular tumours, raising important safety concerns.

PMID:
20147986
DOI:
10.1038/nature08751
[Indexed for MEDLINE]

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