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Nat Rev Cancer. 2010 Mar;10(3):194-204. doi: 10.1038/nrc2803. Epub 2010 Feb 11.

Microtubules and resistance to tubulin-binding agents.

Author information

1
Children's Cancer Institute Australia for Medical Research, Randwick, NSW 2031, Australia. mkavallaris@ccia.unsw.edu.au

Erratum in

  • Nat Rev Cancer. 2010 Apr;10(4):309.

Abstract

Microtubules are dynamic structures composed of alpha-beta-tubulin heterodimers that are essential in cell division and are important targets for cancer drugs. Mutations in beta-tubulin that affect microtubule polymer mass and/or drug binding are associated with resistance to tubulin-binding agents such as paclitaxel. The aberrant expression of specific beta-tubulin isotypes, in particular betaIII-tubulin, or of microtubule-regulating proteins is important clinically in tumour aggressiveness and resistance to chemotherapy. In addition, changes in actin regulation can also mediate resistance to tubulin-binding agents. Understanding the molecular mechanisms that mediate resistance to tubulin-binding agents will be vital to improve the efficacy of these agents.

PMID:
20147901
DOI:
10.1038/nrc2803
[Indexed for MEDLINE]

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