Novel hot spot of IS6110 insertion in Mycobacterium tuberculosis

Elizabeth Y Kim; Payam Nahid; Philip C Hopewell; Midori Kato-Maeda

doi:10.1128/JCM.02210-09

Novel hot spot of IS6110 insertion in Mycobacterium tuberculosis

J Clin Microbiol. 2010 Apr;48(4):1422-4. doi: 10.1128/JCM.02210-09. Epub 2010 Feb 10.

Authors

Elizabeth Y Kim¹, Payam Nahid, Philip C Hopewell, Midori Kato-Maeda

Affiliation

¹ Division of Pulmonary and Critical Care Medicine, Department of Medicine, San Francisco General Hospital, Francis J Curry National Tuberculosis Center, University of California, San Francisco, California, USA.

Abstract

We describe a hot spot for the insertion of IS6110 in Mycobacterium tuberculosis located in the area of region of difference 724 (RD724). Because RD724 defines sublineage 724 of M. tuberculosis, caution must be exercised when screening for RD724, as different polymorphisms can be observed in this region.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

MeSH terms

DNA Transposable Elements*
DNA, Bacterial / genetics*
Humans
Mutagenesis, Insertional*
Mycobacterium tuberculosis / genetics*
Polymorphism, Genetic*

Substances

DNA Transposable Elements
DNA, Bacterial

Abstract

Publication types

MeSH terms

Substances

Grants and funding