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Ann N Y Acad Sci. 2010 Jan;1183:123-48. doi: 10.1111/j.1749-6632.2009.05124.x.

New insights into T cell biology and T cell-directed therapy for autoimmunity, inflammation, and immunosuppression.

Author information

1
Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. stewardtharpsm@mail.nih.gov

Abstract

T cell-directed therapies have become mainstays in the management of various autoimmune diseases and organ transplantation. The understanding of T cell biology has expanded greatly since the development of most agents currently in use. Here we discuss important recent discoveries pertaining to T helper cell differentiation, lineage commitment, and function. Within this context, we examine existing T cell-directed therapies, including new agents being evaluated in clinical and preclinical studies. We also use recent findings to speculate on novel targets.

PMID:
20146712
PMCID:
PMC2950114
DOI:
10.1111/j.1749-6632.2009.05124.x
[Indexed for MEDLINE]
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