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Curr Opin Immunol. 2010 Apr;22(2):161-7. doi: 10.1016/j.coi.2010.01.010. Epub 2010 Feb 9.

Transcription control of early B cell differentiation.

Author information

1
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology, Freiburg, Germany.

Abstract

Differentiation of B lymphocytes involves the step-wise acquisition of a specialized phenotype that depends on the expression of lineage-specific genes and the repression of genes characteristic of multipotent progenitors and alternate lineages. The early steps of B lineage specification and commitment are, partly, controlled by the well-characterized transcription factors Ikaros, Pu.1, E2A, early B cell factor-1, and Pax5 that act in a complex regulatory network. However, our understanding of B cell differentiation is far from complete. Recent work has shed light on the mechanisms by which transcription factors implement cell type-specific gene expression patterns and epigenetic changes in chromatin that allow for B lineage specification and commitment.

PMID:
20144854
DOI:
10.1016/j.coi.2010.01.010
[Indexed for MEDLINE]

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