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Semin Cell Dev Biol. 2010 Aug;21(6):616-21. doi: 10.1016/j.semcdb.2010.02.001. Epub 2010 Feb 6.

The role of mucin-type O-glycans in eukaryotic development.

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1
Section on Biological Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. tabakl@mail.nih.gov

Abstract

Newly emerging genetic studies have revealed that a subset of the family of glycosyltransferases responsible for the formation of mucin-type O glycans is essential for normal development. As additional genetic, biochemical and physical tools are developed to interrogate the complex structure and surface location of this under-studied class of carbohydrate, no doubt additional roles will be elucidated.

PMID:
20144722
PMCID:
PMC2902666
DOI:
10.1016/j.semcdb.2010.02.001
[Indexed for MEDLINE]
Free PMC Article
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