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Epidemiol Infect. 2010 Oct;138(10):1459-67. doi: 10.1017/S0950268810000208. Epub 2010 Feb 10.

Prevalence and clinical correlations of genetic subtypes of Giardia lamblia in an urban setting.

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1
Centre for Infection, Division of Cellular and Molecular Medicine, St George's University of London, London, UK. aodhan.breathnach@stgeorges.nhs.uk

Abstract

The clinical significance of different genetic subtypes or assemblages of Giardia lamblia is uncertain. Cases of giardiasis in south-west London between 1999 and 2005 were studied, comparing molecular-typing results with clinical and epidemiological findings from routine surveillance. We identified 819 cases, of whom 389 returned surveillance questionnaires. A subset of 267 faecal samples was submitted for typing by sequencing of the triose phosphate isomerase (tpi) and ribosomal RNA genes, and/or a separate duplex PCR of the tpi gene. Typing was successful in 199 (75%) samples by at least one of the molecular methods. Assemblage A accounted for 48 (24%) samples and Assemblage B for 145 (73%); six (3%) were mixed. Both assemblages had similar seasonality, age distribution and association with travel. Clinical features were available for 59 successfully typed cases: both assemblages caused similar illness, but Assemblage A was significantly more frequently associated with fever than Assemblage B.

PMID:
20144251
DOI:
10.1017/S0950268810000208
[Indexed for MEDLINE]

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