Send to

Choose Destination
Epidemiol Infect. 2010 Oct;138(10):1459-67. doi: 10.1017/S0950268810000208. Epub 2010 Feb 10.

Prevalence and clinical correlations of genetic subtypes of Giardia lamblia in an urban setting.

Author information

Centre for Infection, Division of Cellular and Molecular Medicine, St George's University of London, London, UK.


The clinical significance of different genetic subtypes or assemblages of Giardia lamblia is uncertain. Cases of giardiasis in south-west London between 1999 and 2005 were studied, comparing molecular-typing results with clinical and epidemiological findings from routine surveillance. We identified 819 cases, of whom 389 returned surveillance questionnaires. A subset of 267 faecal samples was submitted for typing by sequencing of the triose phosphate isomerase (tpi) and ribosomal RNA genes, and/or a separate duplex PCR of the tpi gene. Typing was successful in 199 (75%) samples by at least one of the molecular methods. Assemblage A accounted for 48 (24%) samples and Assemblage B for 145 (73%); six (3%) were mixed. Both assemblages had similar seasonality, age distribution and association with travel. Clinical features were available for 59 successfully typed cases: both assemblages caused similar illness, but Assemblage A was significantly more frequently associated with fever than Assemblage B.

[Indexed for MEDLINE]

Publication type, MeSH terms, Substances, Secondary source ID

Publication type

MeSH terms


Secondary source ID

Supplemental Content

Full text links

Icon for Cambridge University Press
Loading ...
Support Center