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J Cell Biol. 2010 Feb 8;188(3):305-12. doi: 10.1083/jcb.200905111.

Tapping into the glial reservoir: cells committed to remaining uncommitted.

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1
Zilkha Neurogenetic Institute, Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

Abstract

The development and maturation of the oligodendrocyte requires a series of highly orchestrated events that coordinate the proliferation and differentiation of the oligodendrocyte precursor cell (OPC) as well as the spatiotemporal regulation of myelination. In recent years, widespread interest has been devoted to the therapeutic potential of adult OPCs scattered throughout the central nervous system (CNS). In this review, we highlight molecular mechanisms controlling OPC differentiation during development and the implication of these mechanisms on adult OPCs for remyelination. Cell-autonomous regulators of differentiation and the heterogeneous microenvironment of the developing and the adult CNS may provide coordinated inhibitory cues that ultimately maintain a reservoir of uncommitted glia.

PMID:
20142420
PMCID:
PMC2819683
DOI:
10.1083/jcb.200905111
[Indexed for MEDLINE]
Free PMC Article
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