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Chem Biol. 2010 Jan 29;17(1):6-8. doi: 10.1016/j.chembiol.2010.01.002.

Mechanism-based neddylation inhibitor.

Author information

1
Signal Transduction Program, NCI Cancer Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. petroski@burnham.org

Abstract

Brownell et al. (2010) elucidate the mechanism of action of MLN4924, a NEDD8-activating enzyme inhibitor. MLN4924 requires the activity of the enzyme to generate a NEDD8-adenylate analog that potently and selectively shuts down this posttranslational modification system.

PMID:
20142034
DOI:
10.1016/j.chembiol.2010.01.002
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