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Oncogene. 2010 Apr 22;29(16):2357-67. doi: 10.1038/onc.2009.511. Epub 2010 Feb 8.

Lysine methylation regulates the pRb tumour suppressor protein.

Author information

1
Department of Clinical Pharmacology, Medical Sciences Division, University of Oxford, Oxford, UK.

Abstract

The pRb tumour suppressor protein has a central role in coordinating early cell cycle progression. An important level of control imposed on pRb occurs through post-translational modification, for example, phosphorylation. We describe here a new level of regulation on pRb, mediated through the targeted methylation of lysine residues, by the methyltransferase Set7/9. Set7/9 methylates the C-terminal region of pRb, both in vitro and in cells, and methylated pRb interacts with heterochromatin protein HP1. pRb methylation is required for pRb-dependent cell cycle arrest and transcriptional repression, as well as pRb-dependent differentiation. Our results indicate that methylation can influence the properties of pRb, and raise the interesting possibility that methylation modulates pRb tumour suppressor activity.

PMID:
20140018
DOI:
10.1038/onc.2009.511
[Indexed for MEDLINE]

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