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Nat Genet. 2010 Mar;42(3):197-9. doi: 10.1038/ng.532. Epub 2010 Feb 7.

Common variants near TERC are associated with mean telomere length.

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1
Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK.

Erratum in

  • Nat Genet. 2010 Mar;42(3):following 199. Aviv, Abraham [added]; Kimura, Masayuki [added].

Abstract

We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 x 10(-14)) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an approximately 75-base-pair reduction in mean telomere length, equivalent to approximately 3.6 years of age-related telomere-length attrition.

PMID:
20139977
PMCID:
PMC3773906
DOI:
10.1038/ng.532
[Indexed for MEDLINE]
Free PMC Article
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