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Nat Neurosci. 2010 Mar;13(3):281-3. doi: 10.1038/nn.2494. Epub 2010 Feb 7.

Bimodal control of stimulated food intake by the endocannabinoid system.

Author information

1
INSERM U862, NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France.

Abstract

Activation of cannabinoid type-1 receptors (CB(1)) is universally recognized as a powerful endogenous orexigenic signal, but the detailed underlying neuronal mechanisms are not fully understood. Using combined genetic and pharmacological approaches in mice, we found that ventral striatal CB(1) receptors exerted a hypophagic action through inhibition of GABAergic transmission. Conversely, brain CB(1) receptors modulating excitatory transmission mediated the well-known orexigenic effects of cannabinoids.

PMID:
20139974
DOI:
10.1038/nn.2494
[Indexed for MEDLINE]

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