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Clin Nucl Med. 2009 Dec;34(12):886-90. doi: 10.1097/RLU.0b013e3181bece11.

F-18 FDG PET/CT characterization of talc pleurodesis-induced pleural changes over time: a retrospective study.

Author information

1
Division of Nuclear Medicine, Department of Radiology, School of Medicine, St. Louis University, St. Louis, MO 63110, USA. nguyenn@slu.edu

Abstract

PURPOSE:

The current study characterized pleural changes induced by talc pleurodesis (TP), based on serial positron emission tomography/computer-tomography (PET/CT) with F-18 fluorodeoxyglucose (FDG).

MATERIALS AND METHODS:

A total of 8 cancer patients who had both TP and PET/CT and no evidence of active pleural involvement after TP were retrospectively evaluated. Maximum standard uptake values, maximum Hounsfield units (HU), and thickness were followed over time.

RESULTS:

The 8 patients had 25 PET/CT scans performed in an average of 22 months after TP. An increased FDG uptake was associated with an increase in pleural thickness within 5 months after TP, and both parameters showed statistical significance as compared with findings before TP. After 5 months of TP, the standard uptake value appeared to persist or increase further, and the pleural thickening stabilized. The formation of calcification was a slow process and might lag behind the changes in FDG metabolism and pleural thickness. The HU did not change significantly once pleural calcification had been formed.

CONCLUSIONS:

Knowledge of aforementioned pleural changes may help differentiate TP induced pleural inflammation from pleural malignancy and to avoid false-positive interpretation of FDG PET/CT exams.

PMID:
20139823
DOI:
10.1097/RLU.0b013e3181bece11
[Indexed for MEDLINE]

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